Aminooxy-PEG3-azide
Names
[ CAS No. ]:
1306615-51-9
[ Name ]:
Aminooxy-PEG3-azide
[Synonym ]:
O-(11-azido-3,6,9-trioxa-undecyl)hydroxylamine
Biological Activity
[Description]:
Aminooxy-PEG3-azide is a non-cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Aminooxy-C2-PEG3-azide is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[2].
[Related Catalog]:
[Target]
PEGs
Non-cleavable
[In Vitro]
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
[References]
Chemical & Physical Properties
[ Molecular Formula ]:
C8H18N4O4
[ Molecular Weight ]:
234.25300
[ Exact Mass ]:
234.13300
[ PSA ]:
112.69000
[ LogP ]:
0.38986
[ Storage condition ]:
2-8°C