2,2'-DICHLOROBIPHENYL
Names
[ CAS No. ]:
13029-08-8
[ Name ]:
2,2'-DICHLOROBIPHENYL
[Synonym ]:
1-chloro-2-(2-chlorophenyl)benzene
Chemical & Physical Properties
[ Density]:
1.249g/cm3
[ Boiling Point ]:
289.1ºC at 760mmHg
[ Melting Point ]:
79-80℃ (hexane )
[ Molecular Formula ]:
C12H8Cl2
[ Molecular Weight ]:
223.09800
[ Flash Point ]:
122.4ºC
[ Exact Mass ]:
222.00000
[ LogP ]:
4.66040
[ Vapour Pressure ]:
0.00389mmHg at 25°C
[ Index of Refraction ]:
1.594
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- DV3900000
- CHEMICAL NAME :
- Biphenyl, 2,2'-dichloro-
- CAS REGISTRY NUMBER :
- 13029-08-8
- LAST UPDATED :
- 199710
- DATA ITEMS CITED :
- 7
- MOLECULAR FORMULA :
- C12-H8-Cl2
- MOLECULAR WEIGHT :
- 223.10
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 150 mg/kg/3D-I
- TOXIC EFFECTS :
- Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other esterases Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other Enzymes
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 33,94,1975
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 25 mg/kg/20D-I
- TOXIC EFFECTS :
- Immunological Including Allergic - decrease in humoral immune response
- REFERENCE :
- JEPOEC Journal of Environmental Pathology, Toxicology and Oncology. (Chem-Orbital, POB 134, Park Forest, IL 60466) V.5(4)- 1984- Volume(issue)/page/year: 9,283,1989
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intramuscular
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 25 mg/kg/20D-I
- TOXIC EFFECTS :
- Liver - other changes
- REFERENCE :
- JEPOEC Journal of Environmental Pathology, Toxicology and Oncology. (Chem-Orbital, POB 134, Park Forest, IL 60466) V.5(4)- 1984- Volume(issue)/page/year: 12,17,1993 ** REPRODUCTIVE DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 1125 mg/kg
- SEX/DURATION :
- female 1-3 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
- REFERENCE :
- ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year: 40,249,1978
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 1500 mg/kg
- SEX/DURATION :
- female 1-3 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea)
- REFERENCE :
- ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year: 40,249,1978
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 1125 mg/kg
- SEX/DURATION :
- female 1-3 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Maternal Effects - parturition
- REFERENCE :
- BECTA6 Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966- Volume(issue)/page/year: 16,33,1976
Safety Information
[ Symbol ]:
GHS08, GHS09
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H373-H410
[ Precautionary Statements ]:
P273-P391-P501
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves
[ Hazard Codes ]:
N: Dangerous for the environment;
[ Risk Phrases ]:
R33
[ Safety Phrases ]:
S35
[ RIDADR ]:
UN 2315
[ RTECS ]:
DV3900000
[ Packaging Group ]:
II
Synthetic Route
Articles
PLoS ONE 8(1) , e52550, (2013)
The oxidative degradation of biphenyl and polychlorinated biphenyls (PCBs) is initiated in Pandoraea pnomenusa B-356 by biphenyl dioxygenase (BPDO(B356)). BPDO(B356), a heterohexameric (αβ)(3) Rieske ...
Possible molecular targets of halogenated aromatic hydrocarbons in neuronal cells.Biochem. Biophys. Res. Commun. 280(5) , 1372-7, (2001)
Halogenated aromatic hydrocarbon including polychlorinated biphenyls (PCBs) are persistent and bioaccumulative environmental toxicants. Although health effects associated with exposure to these chemic...
Comparative toxicokinetics of 2,2'- and 4,4'-dichlorobiphenyls in the pond snail Lymnaea stagnalis (L.).Arch. Environ. Contam. Toxicol. 19(4) , 565-71, (1990)
Pond snails (Lymnaea stagnalis (L.)) were treated with 2,2'-dichlorobiphenyl (DCB) or 4,4'-DCB, to examine the toxicokinetic profile of these compounds. Snails were treated orally with 210 micrograms ...