2',4'-Dihydroxy-3',6'-dimethoxychalcone

Names

[ Name ]:
2',4'-Dihydroxy-3',6'-dimethoxychalcone

[Synonym ]:
(2Z)-1-(2,4-Dihydroxy-3,6-dimethoxyphenyl)-3-phenyl-2-propen-1-one
2',4'-dihydroxy-3',6'-dimethoxychalcone
2-Propen-1-one, 1-(2,4-dihydroxy-3,6-dimethoxyphenyl)-3-phenyl-, (2Z)-
Benzaldehyde,2,4-dihydroxy-3,5-dimethoxy

Biological Activity

[Description]:

2',4'-Dihydroxy-3',6'-dimethoxychalcone is a natural product that can be isolated from Polygonum Lapathifolium. 2',4'-Dihydroxy-3',6'-dimethoxychalcone inhibits the growth of CCRF-CEM leukaemia cells and CEM/ADR5000 cells, with IC50 values of 10.67 and 18.60 μM, respectively[1][2].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[References]

[1]. Ahmed M, et al. Isoflavan-4-ol, dihydrochalcone and chalcone derivatives from Polygonum Lapathifolium. Phytochemistry, 1990, 29(6):2009-2011.

[2]. Nkuété AH, et al. Anti-leukemia activity of semi-synthetic phenolic derivatives from Polygonum limbatum Meisn. Chem Cent J. 2015 Jun 24;9:40.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
556.0±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₇H₁₆O₅

[ Molecular Weight ]:
300.306

[ Flash Point ]:
207.3±23.6 °C

[ Exact Mass ]:
300.099762

[ PSA ]:
75.99000

[ LogP ]:
3.41

[ Vapour Pressure ]:
0.0±1.6 mmHg at 25°C

[ Index of Refraction ]:
1.637

Safety Information

[ Hazard Codes ]:
Xi

[ HS Code ]:
2914509090

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2914509090

[ Summary ]:
HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%