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PKSI-527

Names

[ CAS No. ]:
128837-71-8

[ Name ]:
PKSI-527

[Synonym ]:
H-Tra-L-Phe-4-carboxymethylanilide hydrochloride
Pksi 527
PKSI-0527
C25H31N3O4.HCl
t-AMCHA-Phe-p-APAA

Biological Activity

[Description]:

PKSI-527 is a new, highly selective plasma kallikrein inhibitor. PKSI-527 can suppress collagen-induced arthritis (CIA) by modifying the kallikrein-kinin system[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Ser/Thr Protease
Research Areas >> Inflammation/Immunology

[References]

[1]. Fujimori Y, et al. Effects of a highly selective plasma kallikrein inhibitor on collagen-induced arthritis in mice. Agents Actions. 1993 May;39(1-2):42-8.  

Chemical & Physical Properties

[ Boiling Point ]:
763.1ºC at 760mmHg

[ Molecular Formula ]:
C25H32ClN3O4

[ Molecular Weight ]:
473.99

[ Flash Point ]:
415.3ºC

[ Exact Mass ]:
473.20800

[ PSA ]:
125.01000

[ LogP ]:
5.16040

[ Vapour Pressure ]:
1.74E-24mmHg at 25°C

Related Compounds