2-PCCA

Names

[ Name ]:
2-PCCA

[Synonym ]:
Cyclopropanecarboxamide, N-[(2S,3S)-2-amino-3-methylpentyl]-N-(4'-propyl[1,1'-biphenyl]-4-yl)-2-(2-pyridinyl)-, (1R,2R)-
compound 2 [PMID: 24793972]
(1R,2R)-N-[(2S,3S)-2-Amino-3-methylpentyl]-N-(4'-propyl-4-biphenylyl)-2-(2-pyridinyl)cyclopropanecarboxamide

Biological Activity

[Description]:

A potent, selective agonist of the orphan GPR88 receptor with EC50 of 877 nM; inhibits isoproterenol-stimulated cAMP accumulation in a concentration-dependent manner in cells expressing GPR88 through a Gαi-coupled pathway; dose-dependently decreases the locomotor activity in rats at 0.1-3.2mg/kg, also decreases methamphetamine-induced hyperactivity combined with methamphetamine; does not alter the behavioral effects of methamphetamine in rats alone.

[References]

References 1. Li JX, et al. Eur J Pharmacol. 2013 Jan 5;698(1-3):272-7. 2. Jin C, et al. ACS Chem Neurosci. 2014 Jul 16;5(7):576-87. 3. Jin C, et al. ACS Chem Neurosci. 2016 Oct 19;7(10):1418-1432. View Related Products by Target GPR88

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
623.4±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₃₀H₃₇N₃O

[ Molecular Weight ]:
455.634

[ Flash Point ]:
330.8±31.5 °C

[ Exact Mass ]:
455.293671

[ LogP ]:
5.61

[ Vapour Pressure ]:
0.0±1.8 mmHg at 25°C

[ Index of Refraction ]:
1.601

Related Compounds

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