NH2-PEG6-Boc

Names

[ Name ]:
NH2-PEG6-Boc

[Synonym ]:
H2N-PEG6-tBu
Amino-PEG6-t-butyl ester

Biological Activity

[Description]:

NH2-PEG6-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. NH2-PEG6-Boc is also a non-cleavable 6 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

Alkyl/ether

Non-cleavable

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[2].

[References]

[1]. Foley CA, et al. Assessing the Cell Permeability of Bivalent Chemical Degraders Using the Chloroalkane Penetration Assay. ACS Chem Biol. 2020 Jan 17;15(1):290-295.

[2]. Kenneth John DIRICO, et al. Spliceostatin analogs. WO2014068443A1.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₉H₃₉NO₈

[ Molecular Weight ]:
409.51500

[ Exact Mass ]:
409.26800

[ PSA ]:
107.70000

[ LogP ]:
1.47680

Related Compounds

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