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ASP6432

Names

[ CAS No. ]:
1282549-08-9

[ Name ]:
ASP6432

Biological Activity

[Description]:

ASP6432 is a potent and selective type 1 lysophosphatidic acid receptor (LPA1) antagonist with IC50s of 11 nM and 30 nM for human LPA1 and rat LPA1, respectively[1].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> GPCR/G Protein >> LPL Receptor

[Target]

IC50: 11 nM (human LPA1), 30 nM (rat LPA1)[1]


[In Vitro]

ASP6432 inhibits the LPA-induced proliferation of human prostate stromal cells[1].

[References]

[1]. Sakamoto K, et al. Effect of ASP6432, a Novel Type 1 Lysophosphatidic Acid Receptor Antagonist, on Urethral Function and Prostate Cell Proliferation. J Pharmacol Exp Ther. 2018 Aug;366(2):390-396.

Chemical & Physical Properties

[ Molecular Formula ]:
C26H31KN4O6S2

[ Molecular Weight ]:
598.78

Related Compounds