p-SCN-Bn-DOTA

Names

[ Name ]:
p-SCN-Bn-DOTA

[Synonym ]:
UNII-13KT123BYW
2-(4-isothiocyanatobenzyl)-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid
cDOTA-Bnz-NCS
p-isothiocyanatobenzyl-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid
1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid,2-((4-isothiocyanatophenyl)methyl)
2-(p-Isothiocyanatobenzyl)-1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraaceticacid
p-SCN-Bz-DOTA
p-SCN-Bn-DOTA
2-(p-isothiocyanatobenzyl)-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid

Biological Activity

[Description]:

p-SCN-Bn-DOTA is a bifunctional chelating agent. p-SCN-Bn-DOTA can simultaneously chelate radionuclides and link monoclonal antibody for radioimmunotherapy of tumor[1][2].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[In Vitro]

p-SCN-Bn-DOTA is complexed with 5 different metal ions: In(III), Y(III), Lu(III), Gd(III) and Cu(II)[2].

[References]

[1]. Vera DRB, et, al. Preclinical evaluation of (177)lu-nimotuzumab: a potential tool for radioimmunotherapy of epidermal growth factor receptor-overexpressing tumors. Cancer Biother Radiopharm. 2011 Jun;26(3):287-97.

[2]. Giannini G, et, al. Synthesis and preliminary in vitro evaluation of DOTA-Tenatumomab conjugates for theranostic applications in tenascin expressing tumors. Bioorg Med Chem. 2019 Aug 1;27(15):3248-3253.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₄H₃₃N₅O₈S

[ Molecular Weight ]:
551.61

[ Exact Mass ]:
551.20500

[ PSA ]:
206.61000

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.