SAR 216471 hydrochloride

Names

[ Name ]:
SAR 216471 hydrochloride

[Synonym ]:
1H-Indole-3-carboxamide, 5-chloro-N-[6-[5-methyl-4-(1-oxobutyl)-1H-pyrazol-1-yl]-3-pyridazinyl]-1-[2-(4-methyl-1-piperazinyl)-2-oxoethyl]-, hydrochloride (1:1)
N-[6-(4-Butyryl-5-methyl-1H-pyrazol-1-yl)-3-pyridazinyl]-5-chloro-1-[2-(4-methyl-1-piperazinyl)-2-oxoethyl]-1H-indole-3-carboxamide hydrochloride (1:1)

Biological Activity

[Description]:

SAR-216471 is a potent, highly selective, intravenous and oral, reversible P2Y12 receptor antagonist with binding IC50 of 17 nM; inhibits ADP-induced platelet aggregation in human platelet rich plasma with IC50 of 0.1 uM; exhibits an ED50 of 2.75mg/kg in ex vivo platelet aggregation model in rats.

[References]

References 1. Boldron C, et al. J Med Chem. 2014 Sep 11;57(17):7293-316. 2. Delesque-Touchard N, et al. Thromb Res. 2014 Sep;134(3):693-703. View Related Products by Target P2Y Receptor

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₈H₃₁ClN₈O_3.HCl

[ Molecular Weight ]:
599.511

[ Exact Mass ]:
598.197449

Related Compounds

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