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18:1 DAP

Names

[ CAS No. ]:
127512-29-2

[ Name ]:
18:1 DAP

[Synonym ]:
[3-(dimethylamino)-2-octadec-9-enoyloxypropyl] octadec-9-enoate

Biological Activity

[Description]:

DODAP is a cationic lipid. The ionizable lipid DODAP is a lipid component of the liposome. DODAP can be used to encapsulate siRNA, immunostimulatory chemotherapeutic agents for in vitro and in vivo delivery and so on[1][2][3].

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Inflammation/Immunology

[References]

[1]. Dabbas S, et al. Importance of the liposomal cationic lipid content and type in tumor vascular targeting: physicochemical characterization and in vitro studies using human primary and transformed endothelial cells. Endothelium. 2008;15(4):189-201.

[2]. Hamzah J, et al. Targeted liposomal delivery of TLR9 ligands activates spontaneous antitumor immunity in an autochthonous cancer model. J Immunol. 2009;183(2):1091-1098.

[3]. Liu Q, et al. Biotinylated cyclen-contained cationic lipids as non-viral gene delivery vectors. Chem Biol Drug Des. 2013;82(4):376-383.

Chemical & Physical Properties

[ Density]:
0.916g/cm3

[ Boiling Point ]:
670.148ºC at 760 mmHg

[ Molecular Formula ]:
C41H77NO4

[ Molecular Weight ]:
648.05400

[ Flash Point ]:
359.092ºC

[ Exact Mass ]:
647.58500

[ PSA ]:
55.84000

[ LogP ]:
12.07800

[ Vapour Pressure ]:
0mmHg at 25°C

[ Index of Refraction ]:
1.476

Safety Information

[ Hazard Codes ]:
Xi

Precursor & DownStream

Precursor

DownStream

Related Compounds