Frondoside A

Frondoside A, a natural glycoside extracted from the sea cucumber, Cucumaria frondosa, possesses anticancer, anti-invasive, anti-metastasis, anti-angiogenic and pro-apoptosis properties with high safety[1][2].

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cancer

Signaling Pathways >> Apoptosis >> Caspase

Caspase 3

Caspase-7

Frondoside A (0-5 μM, 24 hours)causes concentration-dependent reduction in viability of lung and breast cancer cells through a caspase 3/7-dependent cell death pathway[2]. Cell Viability Assay[2] Cell Line: LNM35, A549, NCI-H460-Luc2, MDA-MB-435, MCF-7, and HepG2 cells. Concentration: 0-5 μM. Incubation Time: 24 hours. Result: Significantly and concentration-dependently inhibited cellular viability. Apoptosis Analysis[2] Cell Line: LNM35 cells. Concentration: 1-2.5 μM. Incubation Time: 24 hours. Result: Induced caspase-3/7 activity.

Frondoside A (0.01 and 1 mg/kg/ day i.p. for 25 days) significantly decreases the growth, the angiogenesis and lymph node metastasis of LNM35 tumor xenografts in mice, without obvious toxic side-effects[2]. Animal Model: LNM35 xenografts based on Six-week-old athymic NMRI female nude mice (nu/nu)[2]. Dosage: 0.01 and 1 mg/kg. Administration: IP. daily for 25 days. Result: Induced regression of established LNM35 xenografts.

[1]. Sajwani FH, et al. Frondoside A is a potential anticancer agent from sea cucumbers. J Cancer Res Ther. 2019 Jul-Sep;15(5):953-960.

[2]. Attoub S, et al. Frondoside a suppressive effects on lung cancer survival, tumor growth, angiogenesis, invasion, and metastasis. PLoS One. 2013;8(1):e53087.