fludrocortisone

Names

[ CAS No. ]:
127-31-1

[ Name ]:
fludrocortisone

[Synonym ]:
Fludrocortone
(11β)-9-Fluoro-11,17,21-trihydroxypregn-4-ene-3,20-dione
9a-Fluorocortisol
9α-Fluorocortisol
Alflorone
Fluorocortisone
9α-Fluoro-11β,17α,21-trihydroxy-4-pregnene-3,20-dione
9a-Fluorohydrocortisone
Fludrocortisona [INN-Spanish]
Pregn-4-ene-3,20-dione, 9-fluoro-11,17,21-trihydroxy-, (11β)-
MFCD00083333
9-α-Fluoro-17-hydroxycorticosterone
Fluohydrocortisone
(8S,9R,10S,11S,13S,14S,17R)-9-fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one
Fluorocortisol
Florinef
9α-Fluoro-17-hydroxycorticosterone
9-Fluoro-11β,17,21-trihydroxypregn-4-ene-3,20-dione
Astonin-H
9α-Fludrocortisone
9a-Fluoro-17-hydroxycorticosterone
Fluohydrisone
(11b)-9-Fluoro-11,17,21-trihydroxypregn-4-ene-3,20-dione
9-α-Fludrocortisone
EINECS 204-833-2
Fludrone
9α-Fluorohydrocortisone
fludrocortisone

Biological Activity

[Description]:

Fludrocortisone, a synthetic mineralocorticoid with anti-inflammatory activity.

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Mineralocorticoid Receptor

Research Areas >> Inflammation/Immunology

[References]

[1]. Jaal J, et al. Small Cell Lung Cancer Patient with Profound Hyponatremia and Acute Neurological Symptoms: An Effective Treatment with Fludrocortisone. Case Rep Oncol Med. 2015;2015:286029.

[2]. Mori T, et al. Improved efficiency of hypervolemic therapy with inhibition of natriuresis by fludrocortisone in patients with aneurysmal subarachnoid hemorrhage. Journal of Neurosurgery [1999, 91(6):947-952]

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
564.7±50.0 °C at 760 mmHg

[ Melting Point ]:
208-212ºC

[ Molecular Formula ]:
C₂₁H₂₉FO₅

[ Molecular Weight ]:
380.450

[ Flash Point ]:
295.3±30.1 °C

[ Exact Mass ]:
380.199890

[ PSA ]:
94.83000

[ LogP ]:
1.23

[ Vapour Pressure ]:
0.0±3.5 mmHg at 25°C

[ Index of Refraction ]:
1.584

[ Storage condition ]:
Refrigerator

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TU5025000

CHEMICAL NAME :: Pregn-4-ene-3,20-dione, 9-fluoro-11-beta,17,21-trihydroxy-

CAS REGISTRY NUMBER :: 127-31-1

BEILSTEIN REFERENCE NO. :: 3014278

LAST UPDATED :: 199710

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C21-H29-F-O5

MOLECULAR WEIGHT :: 380.50

WISWESSER LINE NOTATION :: L E5 B666 OV MUTJ A1 BF CQ E1 FV1Q FQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 170 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CLDND* Compilation of LD50 Values of New Drugs. (J.R. MacDougal, Dept. of National Health and Welfare, Food and Drug Divisions, 35 John St., Ottawa, Ont., Canada) ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Parenteral

DOSE :: 8750 ug/kg

SEX/DURATION :: female 7 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Maternal Effects - uterus, cervix, vagina

REFERENCE :: JEMEAV Journal of Experimental Medicine. (Rockefeller Univ. Press, 1230 York Ave., New York, NY 10021) V.1- 1896- Volume(issue)/page/year: 102,347,1955

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 100 mg/kg

SEX/DURATION :: female 6-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)

REFERENCE :: 28QFAD "Laboratory Animals in Drug Testing, Symposium of the 5th International Committee on Laboratory Animals, Hanover, 1972," Speigel, A. ed., Stuttgart, Fed. Rep. Ger., Gustav Fischer Verlag, 1973 Volume(issue)/page/year: -,85,1973

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 1 mg/kg

SEX/DURATION :: female 13-16 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetal death

REFERENCE :: 28QFAD "Laboratory Animals in Drug Testing, Symposium of the 5th International Committee on Laboratory Animals, Hanover, 1972," Speigel, A. ed., Stuttgart, Fed. Rep. Ger., Gustav Fischer Verlag, 1973 Volume(issue)/page/year: -,85,1973

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 2 mg/kg

SEX/DURATION :: female 13-16 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)

REFERENCE :: 28QFAD "Laboratory Animals in Drug Testing, Symposium of the 5th International Committee on Laboratory Animals, Hanover, 1972," Speigel, A. ed., Stuttgart, Fed. Rep. Ger., Gustav Fischer Verlag, 1973 Volume(issue)/page/year: -,85,1973

Safety Information

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
63

[ Safety Phrases ]:
22-26-36

[ HS Code ]:
2937210000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2937210000