yGsy2p-IN-H23

Names

[ Name ]:
yGsy2p-IN-H23

Biological Activity

[Description]:

yGsy2p-IN-H23 is a potent and first-in-class inhibitor for yeast glycogen synthase 2 (yGsy2p) with an IC50 of 875 µM for human glycogen synthase 1 (hGYS1). yGsy2p-IN-H23 bounds within the uridine diphosphate glucose binding pocket of yGsy2p. yGsy2p-IN-H23 is used for glycogen storage diseases (GSDs)[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Metabolic Disease

[Target]

IC50: 875 µM (hGYS1)[1]

[In Vitro]

yGsy2p-IN-H23 (H23) has IC50 values against either hGYS1Δ634S8,11N or wild-type hGYS1 of 161 μM and 875 µM, respectively. yGsy2p-IN-H23 exhibits IC50 values of 280 µM and 263 µM in the absence and presence of G6P for yGsy2p against yeast and human glycogen synthase (GS), respectively. yGsy2p-IN-H23 is not in direct competition with G6P[1].

[References]

[1]. Buyun Tang, et al. Discovery and Development of Small-Molecule Inhibitors of Glycogen Synthase. J Med Chem. 2020 Apr 9;63(7):3538-3551.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₃H₂₇N₃O₂

[ Molecular Weight ]:
377.48

Related Compounds

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