Hyzetimibe

Names

[ CAS No. ]:
1266548-74-6

[ Name ]:
Hyzetimibe

Biological Activity

[Description]:

Hyzetimibe is a cholesterol absorption inhibitor. Hyzetimibe blocks the intestinal absorption of cholesterol and phytol. Hyzetimibe is well tolerated in animal models, with an LDmax 2000 mg/kg in rats and an LDmax 500 mg/kg in rhesus monkeys[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Metabolic Disease

[References]

[1]. Ruan Z, et al. Pharmacokinetics, pharmacodynamics, safety, and tolerability of hyzetimibe (HS-25) in healthy Chinese subjects. J Clin Pharmacol. 2014 Oct;54(10):1144-52.  

Chemical & Physical Properties

[ Molecular Formula ]:
C25H21F2NO3

[ Molecular Weight ]:
421.44

Related Compounds