5-(3-bromophenyl)-2,4-dihydro-3H-1,2,4-triazole-3-thione

Names

[ Name ]:
5-(3-bromophenyl)-2,4-dihydro-3H-1,2,4-triazole-3-thione

Biological Activity

[Description]:

Tyrosinase-IN-16 (compound 19a) is a tyrosine kinase (Tyrosinase) inhibitor with Ki=470 nM. Tyrosinase-IN-16 is cytotoxic to B16F10 cells, with >90% inhibition at 20 μM[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Metabolic Enzyme/Protease >> Tyrosinase

[References]

[1]. Choi J, et al. Ensemble-Based Virtual Screening Led to the Discovery of New Classes of Potent Tyrosinase Inhibitors. J Chem Inf Model. 2016 Feb 22;56(2):354-67.

Chemical & Physical Properties

[ Density]:
1.83g/cm3

[ Boiling Point ]:
326.6ºC at 760 mmHg

[ Molecular Formula ]:
C₈H₆BrN₃S

[ Molecular Weight ]:
256.12200

[ Flash Point ]:
151.3ºC

[ Exact Mass ]:
254.94700

[ PSA ]:
76.56000

[ LogP ]:
2.89680

[ Vapour Pressure ]:
0.000214mmHg at 25°C

[ Index of Refraction ]:
1.775

Safety Information

[ HS Code ]:
2933990090

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

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