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AT-9010

Names

[ CAS No. ]:
1261253-79-5

[ Name ]:
AT-9010

Biological Activity

[Description]:

AT-9010, a triphosphate active metabolite of AT-527, is a potent inhibitor of NiRAN (a function essential for viral replication). AT-9010 can inhibit SARS-CoV-2 replication[1].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> Anti-infection >> SARS-CoV

[Target]

NiRAN[1]


[In Vitro]

Substantial levels of the active triphosphate metabolite AT-9010 are formed in normal human bronchial and nasal epithelial cells incubated with 10 µM AT-511 (698 µM and 236 µM, respectively), with a half-life of at least 38 hours[1].

[References]

[1]. Atea Pharmaceuticals Announces Publication of Preclinical Data Highlighting Potent Activity of AT-527 Against SARS-CoV-2. BOSTON, Feb. 08, 2021. Atea Pharmaceuticals, Inc.

Chemical & Physical Properties

[ Molecular Formula ]:
C11H17FN5O13P3

[ Molecular Weight ]:
539.20

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds