Dimiracetam

Names

[ Name ]:
Dimiracetam

[Synonym ]:
2,5-dioxohexahydro-1H-pyrrolo[1,2-a]imidazole
tetrahydro-pyrrolo[1,2-a]imidazole-2,5-dione
dimiracetam
1H-Pyrrolo(1,2-a)imidazole-2,5(3H,6H)-dione,dihydro
(+-)-Dihydro-1H-pyrrolo(1,2-a)imidazole-2,5(3H,6H)-dione
Dimiracetam [INN]

Biological Activity

[Description]:

Dimiracetam is an orally active compound, with anti-neuropathic activity. Dimiracetam inhibits hypersensitivity and neurological alterations, and inhibits Sorafenib (HY-10201)-induced neuropathy in cold stimulation rat models[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[References]

[1]. Di Cesare Mannelli L, et al. A model of neuropathic pain induced by sorafenib in the rat: Effect of dimiracetam. Neurotoxicology. 2015 Sep;50:101-7.

[2]. Di Cesare Mannelli L, et al. A rat model of FOLFOX-induced neuropathy: effects of oral dimiracetam in comparison with duloxetine and pregabalin. Cancer Chemother Pharmacol. 2017 Dec;80(6):1091-1103.

Chemical & Physical Properties

[ Density]:
1.4g/cm3

[ Boiling Point ]:
460.5ºC at 760 mmHg

[ Molecular Formula ]:
C₆H₈N₂O₂

[ Molecular Weight ]:
140.14

[ Flash Point ]:
232.3ºC

[ Exact Mass ]:
140.05900

[ PSA ]:
52.90000

[ Vapour Pressure ]:
1.16E-08mmHg at 25°C

[ Index of Refraction ]:
1.585

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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