Demeton
Names
[ CAS No. ]:
126-75-0
[ Name ]:
Demeton
[Synonym ]:
Diethyl [2-(ethylthio)ethyl] phosphorothionate
PO-Systox
O,O-diethyl S-2-ethylthioethyl phosphorothioate
Demeton
Demetonthiol
O,O-Diethyl S-[2-(ethylsulfanyl)ethyl] phosphorothioate
O,O-Diethyl-S-[2-(ethylsulfanyl)ethyl]thiophosphat
Demeton thiol
ISOSYSTOX
Phosphorothioic acid, O,O-diethyl S-[2-(ethylthio)ethyl] ester
O,O-diethyl S-[2-(ethylthio)ethyl] phosphorothioate
Isodemeton
Thioldemeton
Demeton o,s
mercaptophos thiol
Diethyl 2-(ethylthio)ethyl phosphorothionate
O,O-diethyl-S-2-ethylthioethyl phosphorothioate
Izosystox [Czech]
Systox thiol
MFCD00055359
Izosystox
O,O-diethyl S-[2-(ethylsulfanyl)ethyl] thiophosphate
Disulfoton oxygen analog
1-diethoxyphosphorylsulfanyl-2-ethylsulfanylethane
Thiophosphate de O,O-diéthyle et de S-[2-(éthylsulfanyl)éthyle]
O,O-diethyl S-[2-(ethylthio)ethyl] thiophosphate
Demeton-S
thiophosphoric acid O,O'-diethyl ester-S-(2-ethylsulfanyl-ethyl ester)
Thiol systox
Chemical & Physical Properties
[ Density]:
1.1±0.1 g/cm3
[ Boiling Point ]:
320.5±44.0 °C at 760 mmHg
[ Melting Point ]:
95-97℃
[ Molecular Formula ]:
C8H19O3PS2
[ Molecular Weight ]:
258.338
[ Flash Point ]:
147.6±28.4 °C
[ Exact Mass ]:
258.051331
[ PSA ]:
95.94000
[ LogP ]:
2.38
[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C
[ Index of Refraction ]:
1.493
[ Storage condition ]:
0-6°C
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- TF3130000
- CHEMICAL NAME :
- Phosphorothioic acid, O,O-diethyl S-(2-(ethylthio)ethyl) ester
- CAS REGISTRY NUMBER :
- 126-75-0
- BEILSTEIN REFERENCE NO. :
- 1709166
- LAST UPDATED :
- 199710
- DATA ITEMS CITED :
- 11
- MOLECULAR FORMULA :
- C8-H19-O3-P-S2
- MOLECULAR WEIGHT :
- 258.36
- WISWESSER LINE NOTATION :
- 2S2SPO&O2&O2
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1500 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 217,144,1953
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1500 ug/kg
- TOXIC EFFECTS :
- Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase
- REFERENCE :
- AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60. For publisher information, see AEHLAU. Volume(issue)/page/year: 13,606,1956
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1700 ug/kg
- TOXIC EFFECTS :
- Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase
- REFERENCE :
- BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 6,244,1961
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 5800 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 2(5),7,1958
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 174 ug/kg
- TOXIC EFFECTS :
- Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage)
- REFERENCE :
- PHARAT Pharmazie. (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1946- Volume(issue)/page/year: 35,806,1980
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 6 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 217,144,1953
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 5600 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 7(5),38,1963
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 5 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 2(5),7,1958
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 5500 ug/kg
- TOXIC EFFECTS :
- Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase
- REFERENCE :
- AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60. For publisher information, see AEHLAU. Volume(issue)/page/year: 13,606,1956
Safety Information
[ Symbol ]:
GHS06
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H300 + H310
[ Precautionary Statements ]:
P264-P280-P301 + P310-P302 + P350-P310
[ Hazard Codes ]:
T+: Very toxic;
[ Risk Phrases ]:
R27/28
[ Safety Phrases ]:
S28;S45;S36/S37
[ RIDADR ]:
UN 3018
[ RTECS ]:
TF3130000
[ Packaging Group ]:
I
[ Hazard Class ]:
6.1(a)