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Demeton

Names

[ CAS No. ]:
126-75-0

[ Name ]:
Demeton

[Synonym ]:
Diethyl [2-(ethylthio)ethyl] phosphorothionate
PO-Systox
O,O-diethyl S-2-ethylthioethyl phosphorothioate
Demeton
Demetonthiol
O,O-Diethyl S-[2-(ethylsulfanyl)ethyl] phosphorothioate
O,O-Diethyl-S-[2-(ethylsulfanyl)ethyl]thiophosphat
Demeton thiol
ISOSYSTOX
Phosphorothioic acid, O,O-diethyl S-[2-(ethylthio)ethyl] ester
O,O-diethyl S-[2-(ethylthio)ethyl] phosphorothioate
Isodemeton
Thioldemeton
Demeton o,s
mercaptophos thiol
Diethyl 2-(ethylthio)ethyl phosphorothionate
O,O-diethyl-S-2-ethylthioethyl phosphorothioate
Izosystox [Czech]
Systox thiol
MFCD00055359
Izosystox
O,O-diethyl S-[2-(ethylsulfanyl)ethyl] thiophosphate
Disulfoton oxygen analog
1-diethoxyphosphorylsulfanyl-2-ethylsulfanylethane
Thiophosphate de O,O-diéthyle et de S-[2-(éthylsulfanyl)éthyle]
O,O-diethyl S-[2-(ethylthio)ethyl] thiophosphate
Demeton-S
thiophosphoric acid O,O'-diethyl ester-S-(2-ethylsulfanyl-ethyl ester)
Thiol systox

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
320.5±44.0 °C at 760 mmHg

[ Melting Point ]:
95-97℃

[ Molecular Formula ]:
C8H19O3PS2

[ Molecular Weight ]:
258.338

[ Flash Point ]:
147.6±28.4 °C

[ Exact Mass ]:
258.051331

[ PSA ]:
95.94000

[ LogP ]:
2.38

[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.493

[ Storage condition ]:
0-6°C

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TF3130000
CHEMICAL NAME :
Phosphorothioic acid, O,O-diethyl S-(2-(ethylthio)ethyl) ester
CAS REGISTRY NUMBER :
126-75-0
BEILSTEIN REFERENCE NO. :
1709166
LAST UPDATED :
199710
DATA ITEMS CITED :
11
MOLECULAR FORMULA :
C8-H19-O3-P-S2
MOLECULAR WEIGHT :
258.36
WISWESSER LINE NOTATION :
2S2SPO&O2&O2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1500 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 217,144,1953
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1500 ug/kg
TOXIC EFFECTS :
Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase
REFERENCE :
AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60. For publisher information, see AEHLAU. Volume(issue)/page/year: 13,606,1956
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1700 ug/kg
TOXIC EFFECTS :
Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase
REFERENCE :
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 6,244,1961
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
5800 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 2(5),7,1958
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
174 ug/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage)
REFERENCE :
PHARAT Pharmazie. (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1946- Volume(issue)/page/year: 35,806,1980
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
6 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 217,144,1953
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
5600 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 7(5),38,1963
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
5 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 2(5),7,1958
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
5500 ug/kg
TOXIC EFFECTS :
Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase
REFERENCE :
AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60. For publisher information, see AEHLAU. Volume(issue)/page/year: 13,606,1956

Safety Information

[ Symbol ]:

GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H300 + H310

[ Precautionary Statements ]:
P264-P280-P301 + P310-P302 + P350-P310

[ Hazard Codes ]:
T+: Very toxic;

[ Risk Phrases ]:
R27/28

[ Safety Phrases ]:
S28;S45;S36/S37

[ RIDADR ]:
UN 3018

[ RTECS ]:
TF3130000

[ Packaging Group ]:
I

[ Hazard Class ]:
6.1(a)

Synthetic Route

Precursor & DownStream


Related Compounds