OXA-11

Names

[ Name ]:
OXA-11

Biological Activity

[Description]:

A potent and selective inhibitor of FAK phosphorylation with biochemical IC50 of 1.2 pM (pFAK Y397), cellular IC50 of 1 nM; displays 8-fold selectivity over PYK2, 26-fold selectivity over RSK1/2 , and >1000-fold selectivity over SRC, AURKA, AURKB, INSR, and KDR; suppresses pFAK Y397 and pFAK Y861 in tumors and liver, shows tumor growth inhibition in TOV21G xenografts in mice.

[References]

References 1. Moen I, et al. Clin Exp Metastasis. 2015 Dec;32(8):799-817. View Related Products by Target Focal Adhesion Kinase (FAK)

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₇H₄₉F₃N₇O₅P

[ Molecular Weight ]:
759.812

Related Compounds

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