Ganirelix

Names

[ Name ]:
Ganirelix

Biological Activity

[Description]:

Ganirelix is a competitive and selective gonadotropin releasing hormone (GnRH) antagonist. Ganirelix prevents endogenous GnRH from inducing luteinising hormone (LH) and follicle stimulating hormone relea[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> GNRH Receptor

Research Areas >> Metabolic Disease

[In Vivo]

Ganirelix (0.1 mg/kg; s.c.; daily for 14 d) reduces luteinising hormone levels in female rats[2]. Animal Model: Female Sprague-Dawley rats, weighing 225–300 mg[2] Dosage: 0.1 mg/kg Administration: Subcutaneous injection, daily for 14 d Result: Reduced luteinising hormone levels.

[References]

[1]. Gillies PS, et al. Ganirelix. Drugs. 2000 Jan;59(1):107-11; discussion 112-3.

[2]. Russo A, et al. Effects of the gonadotropin-releasing hormone antagonist ganirelix on normal micturition and prostaglandin E(2)-induced detrusor overactivity in conscious female rats. Eur Urol. 2011 May;59(5):868-74.

Chemical & Physical Properties

[ Density]:
1.31 g/cm3

[ Molecular Formula ]:
C₈₀H₁₁₃ClN₁₈O₁₃

[ Molecular Weight ]:
1570.32000

[ Exact Mass ]:
1568.84000

[ PSA ]:
451.49000

[ LogP ]:
7.99260

Related Compounds

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