AP 811

Names

[ Name ]:
AP 811

Biological Activity

[Description]:

AP 811 is a selective atrial natriuretic peptide clearance receptor (APN-CR, NPR3) antagonist (Ki=0.48 nM). AP 811 displays >20,000-fold selectivity for NPR3 over NPR1. AP 811 abolishes ANP-induced pump stimulation[1][2].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Others >> Others

[References]

[1]. Veale CA, et al. The discovery of non-basic atrial natriuretic peptide clearance receptor antagonists. Part 1. Bioorg Med Chem Lett. 2000;10(17):1949-1952.

[2]. William M, et al. Natriuretic peptides stimulate the cardiac sodium pump via NPR-C-coupled NOS activation. Am J Physiol Cell Physiol. 2008;294(4):C1067-C1073.

Chemical & Physical Properties

[ Density]:
1.33g/cm3

[ Molecular Formula ]:
C₄₆H₆₆N₁₂O₈

[ Molecular Weight ]:
915.09200

[ Exact Mass ]:
914.51300

[ PSA ]:
349.66000

[ LogP ]:
7.99040

[ Index of Refraction ]:
1.635

Related Compounds

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