Necrocide 1

Names

[ Name ]:
Necrocide 1

[Synonym ]:
2H-Indol-2-one,3-cycloheptyl-1,3-dihydro-3-(4-hydroxyphenyl)-6-methoxy-7-methyl-,(3S)

Biological Activity

[Description]:

Necrocide 1 (compound (S)-38) a potent anticancer agent. Necrocide 1 has antiproliferative activity with an IC50 value of 0.48 and 2 nM for MCF-7 and PC3, respectively[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[References]

[1]. Synthesis and Antitumor Effect in Vitro and in Vivo of Substituted 1,3-Dihydroindole-2-onesJ. Med. Chem., Article ASAPDOI: 10.1021/jm100763jPublication Date (Web): September 16, 2010

[2]. Christensen MK, et, al. Synthesis and antitumor effect in vitro and in vivo of substituted 1,3-dihydroindole-2-ones. J Med Chem. 2010 Oct 14;53(19):7140-5.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₃H₂₇NO₃

[ Molecular Weight ]:
365.47

[ Exact Mass ]:
365.19900

[ PSA ]:
62.05000

[ LogP ]:
5.00290

Related Compounds

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