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Sotalol D6 hydrochloride

Names

[ CAS No. ]:
1246820-85-8

[ Name ]:
Sotalol D6 hydrochloride

[Synonym ]:
Methanesulfonamide, N-[4-[1-hydroxy-2-[[1-(methyl-d3)ethyl-2,2,2-d3]amino]ethyl]phenyl]-, hydrochloride (1:1)
N-(4-{1-Hydroxy-2-[(1,1,1,3,3,3-2H6)-2-propanylamino]ethyl}phenyl)methanesulfonamide hydrochloride (1:1)

Biological Activity

[Description]:

Sotalol D6 hydrochloride is a deuterium labeled Sotalol hydrochloride. Sotalol hydrochloride is a non-selective competitive β-adrenergic receptor antagonist that also exhibits Class III antiarrhythmic properties by its inhibition of potassium channels[1][2].

[Related Catalog]:

Research Areas >> Cardiovascular Disease
Research Areas >> Endocrinology
Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor
Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel

[Target]

β-adrenergic receptor[1]; Potassium channels[1]


[References]

[1]. Antonaccio, M.J. and A. Gomoll, Pharmacologic basis of the antiarrhythmic and hemodynamic effects of sotalol. Am J Cardiol, 1993. 72(4): p. 27A-37A.

[2]. Bertrix, L., et al., Protection against ventricular and atrial fibrillation by sotalol. Cardiovasc Res, 1986. 20(5): p. 358-63

Chemical & Physical Properties

[ Molecular Formula ]:
C12H15D6ClN2O3S

[ Molecular Weight ]:
314.862

[ Exact Mass ]:
314.133789

Related Compounds