BCI

Names

[ Name ]:
BCI

[Synonym ]:
(2E)-2-Benzylidene-3-(cyclohexylamino)-1-indanone
1H-Inden-1-one, 3-(cyclohexylamino)-2,3-dihydro-2-(phenylmethylene)-, (2E)-
MFCD20232928

Biological Activity

[Description]:

BCI is an allosteric inhibitor of dual specificity phosphatase (DUSP). BCI specifically inhibits DUSP6 and DUSP1 with EC50s of 13.3 and 8.0 μM in cells, respectively. BCI does not inhibit DUSP5[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphatase

[References]

[1]. Korotchenko VN, et al. In vivo structure-activity relationship studies support allosteric targeting of a dual specificity phosphatase. Chembiochem. 2014 Jul 7;15(10):1436-45.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
484.6±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₂H₂₃NO

[ Molecular Weight ]:
317.424

[ Flash Point ]:
161.3±28.9 °C

[ Exact Mass ]:
317.177979

[ LogP ]:
5.65

[ Vapour Pressure ]:
0.0±1.2 mmHg at 25°C

[ Index of Refraction ]:
1.625

Safety Information

[ Hazard Codes ]:
Xi

BCI

Names

Biological Activity

Chemical & Physical Properties

Safety Information

Related Compounds