(3S,5R)-Rosuvastatin
Names
[ CAS No. ]:
1242184-42-4
[ Name ]:
(3S,5R)-Rosuvastatin
[Synonym ]:
(3S,5R)-Rosuvastatin Sodium Salt
(3S,5R)-Rosuvastatin
Rosuvastatin Acid Enantiomer
Biological Activity
[Description]:
(3S,5R)-Rosuvastatin is the (3S,5R)-enantiomer of Rosuvastatin. Rosuvastatin is a competitive HMG-CoA reductase inhibitor with an IC50 of 11 nM[1]. Rosuvastatin potently blocks human ether-a-go-go related gene (hERG) current with an IC50 of 195 nM[2]. Rosuvastatin reduces the expression of the mature hERG and the interaction of heat shock protein 70 (Hsp70) with the hERG protein. Rosuvastatin is very effective in lowering low-density lipoprotein (LDL) cholesterol, triglycerides, and C-reactive protein levels[3].
[Related Catalog]:
[Target]
IC50: 11 nM (HMG-CoA)[1] and 195 nM (hERG)[2]
[References]
Chemical & Physical Properties
[ Density]:
1.368±0.06 g/cm3
[ Molecular Formula ]:
C22H28FN3O6S
[ Molecular Weight ]:
481.53800
[ Exact Mass ]:
481.16800
[ PSA ]:
149.30000
[ LogP ]:
3.48250
[ Water Solubility ]:
Very slightly soluble (0.17 g/L) (25 ºC)