LMT-28

Names

[ Name ]:
LMT-28

[Synonym ]:
(4S)-3-[(2S,3S)-3-Hydroxy-2-methyl-4-methylene-1-oxononyl]-4-(1-methylethyl)-2-oxazolidinone
2-Oxazolidinone, 3-[(2S,3S)-3-hydroxy-2-methyl-4-methylene-1-oxononyl]-4-(1-methylethyl)-, (4S)-
LMT-28
(4S)-3-[(2S,3S)-3-Hydroxy-2-methyl-4-methylenenonanoyl]-4-isopropyl-1,3-oxazolidin-2-one

Biological Activity

[Description]:

LMT-28 (LMT28) is a specific blocker of IL-6 signaling via inhibits IL-6Rβ (gp130) with IC50 of 5.9 uM (IL-6–induced luciferase activity), selectively inhibits IL-6–induced phosphorylation of STAT3, JAK2, and gp130; does not affect LIF-induced STAT3 activation and not inhibit IL-11 stimulation on HepG2 cells; binds directly and specifically to gp130, and thereby inhibits the interaction of gp130 with the IL-6/IL-6Rα complex; inhibits IL-6–induced proliferation of the human erythroleukemic cell line TF-1 with IC50 of 7.5 uM; inhibits IL-6–induced TNF-α production, ameliorates the progression of pancreatitis in mice.

[References]

References 1. Hong SS, et al. J Immunol. 2015 Jul 1;195(1):237-45. 2. Armstead WM, et al. Transl Stroke Res. 2018 Feb 23. doi: 10.1007/s12975-018-0617-z. View Related Products by Target Interleukin Receptor

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
452.9±38.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₇H₂₉NO₄

[ Molecular Weight ]:
311.417

[ Flash Point ]:
227.7±26.8 °C

[ Exact Mass ]:
311.209656

[ LogP ]:
3.05

[ Vapour Pressure ]:
0.0±2.5 mmHg at 25°C

[ Index of Refraction ]:
1.493

[ Storage condition ]:
-20°C

Related Compounds

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