LSD1-IN-20

Names

[ Name ]:
LSD1-IN-20

Biological Activity

[Description]:

LSD1-IN-20 (compound 1) is a potent dual non-covalent LSD1/G9a inhibitor, with Ki values of 0.44 and 0.68 μM, respectively. LSD1-IN-20 shows antiproliferative activity in THP-1 leukemia cells and MDA-MB-231 breast cancer cells, with IC50 (72 h) of 0.51 and 1.60 μM, respectively[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Epigenetics >> Histone Methyltransferase

Signaling Pathways >> Epigenetics >> Histone Demethylase

[Target]

Ki of 0.440 ± 0.05 μM (LSD1), 0.68 ± 0.02 μM (G9a)[1]

[References]

[1]. Menna M, et al. Novel non-covalent LSD1 inhibitors endowed with anticancer effects in leukemia and solid tumor cellular models. Eur J Med Chem. 2022 Jul 5;237:114410.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₇H₃₈N₆O₂

[ Molecular Weight ]:
478.63

Related Compounds

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