Hydroxyevodiamine

Names

[ Name ]:
Hydroxyevodiamine

[Synonym ]:
(13bS)-10-Hydroxy-14-methyl-8,13,13b,14-tetrahydroindolo[2',3':3,4]pyrido[2,1-b]quinazolin-5(7H)-one
Hydroxy-evodiamin
Indolo[2',3':3,4]pyrido[2,1-b]quinazolin-5(7H)-one, 8,13,13b,14-tetrahydro-13b-hydroxy-14-methyl-
Indolo[2',3':3,4]pyrido[2,1-b]quinazolin-5(7H)-one, 8,13,13b,14-tetrahydro-10-hydroxy-14-methyl-, (13bS)-
13b-Hydroxy-14-methyl-8,13,13b,14-tetrahydroindolo[2',3':3,4]pyrido[2,1-b]quinazolin-5(7H)-one

Biological Activity

[Description]:

Hydroxyevodiamine (Rhetsinine) inhibits aldose reductase with an IC50 value of 24.1 μM[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Aldose Reductase

Research Areas >> Inflammation/Immunology

[References]

[1]. A Kato, et al. Inhibitory effect of rhetsinine isolated from Evodia rutaecarpa on aldose reductase activity. Phytomedicine. 2009 Mar;16(2-3):258-61.

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
633.4±55.0 °C at 760 mmHg

[ Melting Point ]:
190 °C

[ Molecular Formula ]:
C₁₉H₁₇N₃O₂

[ Molecular Weight ]:
319.357

[ Flash Point ]:
336.9±31.5 °C

[ Exact Mass ]:
319.132080

[ PSA ]:
59.57000

[ LogP ]:
0.46

[ Vapour Pressure ]:
0.0±1.9 mmHg at 25°C

[ Index of Refraction ]:
1.797

[ Storage condition ]:
2-8°C

Hydroxyevodiamine

Names

Biological Activity

Chemical & Physical Properties

Precursor & DownStream

Precursor

DownStream

Related Compounds