NC-005

Names

[ Name ]:
NC-005

Biological Activity

[Description]:

A potent, specific immunoproteasome β5 subunit inhibitor with IC50 of 44 nM, 105 and 225-fold selectivity over β2i and β1i subunit, respecitvely; shows cytotoxicity against multiple myeloma cells with IC50 of 30 nM-1.5 uM.

[References]

References 1. Britton M, et al. Chem Biol. 2009 Dec 24;16(12):1278-89. 2. de Bruin G, et al. J Med Chem. 2014 Jul 24;57(14):6197-209. View Related Products by Target Proteasome

Chemical & Physical Properties

[ Molecular Formula ]:
C₄₀H₄₅N₃O₆

[ Molecular Weight ]:
663.815

Related Compounds

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