Fosifidancitinib

Names

[ Name ]:
Fosifidancitinib

[Synonym ]:
2(3H)-Benzoxazolone, 5-[[(4Z)-2-[(4-fluoro-3-methoxy-5-methylphenyl)amino]-5-methyl-4(3H)-pyrimidinylidene]amino]-3-[(phosphonooxy)methyl]-
{5-[(Z)-{2-[(4-Fluoro-3-methoxy-5-methylphenyl)amino]-5-methyl-4(3H)-pyrimidinylidene}amino]-2-oxo-1,3-benzoxazol-3(2H)-yl}methyl dihydrogen phosphate

Biological Activity

[Description]:

Fosifidancitinib is a potent and selective inhibitor of JAK kinases 1/3. Fociatinib is used in studies of allergies, asthma and autoimmune diseases[1].

[Related Catalog]:

Signaling Pathways >> JAK/STAT Signaling >> JAK

Signaling Pathways >> Epigenetics >> JAK

Signaling Pathways >> Stem Cell/Wnt >> JAK

Research Areas >> Inflammation/Immunology

[References]

[1]. Li, Hui; Heckrodt, Thilo J.; Chen, Yan; Mcmurtrie, Darren John; Taylor, Vanessa; Singh, Rajinder; Ding, Pingyu; Yen, Rose.Preparation of phenylaminopyrimidinylaminooxobenzooxazole derivatives for use as JAK kinase inhibitors. WO2012015972A1

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
723.1±70.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₁H₂₁FN₅O₇P

[ Molecular Weight ]:
505.39

[ Flash Point ]:
391.1±35.7 °C

[ Exact Mass ]:
505.116272

[ LogP ]:
2.15

[ Vapour Pressure ]:
0.0±2.5 mmHg at 25°C

[ Index of Refraction ]:
1.680

Related Compounds

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