GX-936

Names

[ Name ]:
GX-936

Biological Activity

[Description]:

GX-936 (PF 05196233) is a potent Nav1.7 inhibitor that binds to the activated state of voltage-sensor domain IV (VSD4), exhibits robust inhibition of the 1KαPMTX-evoked N1742K response with IC50 of 40 nM; inhibits Nav1.7 through a voltage-sensor trapping mechanism, likely by stabilizing inactivated states of the channel.

[References]

References 1. Ahuja S, et al. Science. 2015 Dec 18;350(6267):aac5464. 2. Chernov-Rogan T, et al. Proc Natl Acad Sci U S A. 2018 Jan 23;115(4):E792-E801. View Related Products by Target Sodium Channel

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₄H₂₀F₃N₇O₃S₂

[ Molecular Weight ]:
575.585

Related Compounds

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