RV1088

Names

[ Name ]:
RV1088

[Synonym ]:
2-Methoxy-N-(4-{[4-({[1-(4-methylphenyl)-3-(2-methyl-2-propanyl)-1H-pyrazol-5-yl]carbamoyl}amino)-1-naphthyl]oxy}-2-pyridinyl)acetamide
Acetamide, N-[4-[[4-[[[[3-(1,1-dimethylethyl)-1-(4-methylphenyl)-1H-pyrazol-5-yl]amino]carbonyl]amino]-1-naphthalenyl]oxy]-2-pyridinyl]-2-methoxy-

Biological Activity

[Description]:

RV1088 is a potent narrow spectrum kinase inhibitor that target p38, c-Src, Syk or JAK individually, dose-dependently reduces TNF-α levels in LPS-activated macrophages with IC50 of 0.63 nM; also reduces IL-6 production effectively with IC50 of 1.66 nM, RV1088 is significantly more effective at inhibiting IL-6 and IL-8 production by monocytes and RA synovial fibroblasts compared with Humira; TNF-α, IL-6 and IL-8 synthesis in RA synovial membrane cells with low nM IC50s.

[References]

References 1. To WS, et al. Br J Pharmacol. 2015 Aug;172(15):3805-16. View Related Products by Target p38 MAPK

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
706.1±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C₃₃H₃₄N₆O₄

[ Molecular Weight ]:
578.661

[ Flash Point ]:
380.8±32.9 °C

[ Exact Mass ]:
578.264160

[ LogP ]:
7.62

[ Vapour Pressure ]:
0.0±2.2 mmHg at 25°C

[ Index of Refraction ]:
1.632

Related Compounds

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