Sabutoclax

Names

[ Name ]:
Sabutoclax

[Synonym ]:
1,1',6,6',7,7'-hexahydroxy-3,3'-dimethyl-N5,N5'-bis(2-phenylpropyl)-2,2'-binaphthyl-5,5'-dicarboxamide
[2,2'-Binaphthalene]-5,5'-dicarboxamide, 1,1',6,6',7,7'-hexahydroxy-3,3'-dimethyl-N,N-bis[(2R)-2-phenylpropyl]-
UNII:39Y89ZRK34
1,1',6,6',7,7'-HEXAHYDROXY-3,3'-DIMETHYL-N5-((R)-2-PHENYLPROPYL)-N5'-((R)-2-PHENYLPROPYL)-2,2'-BINAPHTHYL-5,5'-DICARBOXAMIDE (ATROPISOMERIC MIX)
Sabutoclax
UNII-39Y89ZRK34
1,1',6,6',7,7'-Hexahydroxy-3,3'-dimethyl-N,N'-bis[(2R)-2-phenylpropyl]-2,2'-binaphthalene-5,5'-dicarboxamide
BI-97C1

Biological Activity

[Description]:

Sabutoclax is a potent and effective Bcl-2 Family (Bcl-2, Bcl-XL, Mcl-1, Bfl-1) inhibitor with IC50s of 0.32 μM, 0.31 μM, 0.20 μM, and 0.62 μM, respectively.

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Bcl-2 Family

Research Areas >> Cancer

[Target]

Bcl-xL:0.31 μM (IC50)

BCL2:0.32 μM (IC50)

Mcl-1:0.2 μM (IC50)

Bfl-1:0.62 μM (IC50)

[References]

[1]. Wei J , et al. BI-97C1, an optically pure Apogossypol derivative as pan-active inhibitor of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins. J Med Chem. 2010 May 27; 53(10):4166-76.

[Related Small Molecules]

Venetoclax (ABT-199) | ABT-263 | S63845 | ABT-737 | Obatoclax Mesylate | A-1210477 | A-1155463 | WEHI-539 hydrochloride | A-1331852 | Bax inhibitor peptide V5 | FX 1 | Gambogic Acid | TW-37 | UMI-77 | Acetate gossypol

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
905.9±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C₄₂H₄₀N₂O₈

[ Molecular Weight ]:
700.776

[ Flash Point ]:
501.7±34.3 °C

[ Exact Mass ]:
700.278442

[ PSA ]:
186.56000

[ LogP ]:
7.47

[ Vapour Pressure ]:
0.0±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.713

[ Storage condition ]:
-20℃

Related Compounds

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