MeIQx-d3

Names

[ Name ]:
MeIQx-d3

[Synonym ]:
MeIQx-d3

Biological Activity

[Description]:

MeIQx-d3 is the deuterium labeled MeIQx (HY-W355129)[1]. MeIQx is a heterocyclic amine (HAs) compound and a dietary aromatic amine, which can bind covalently to hemoglobin. MeIQx is a mutagenic compound that induces liver tumors[2].

[Related Catalog]:

Research Areas >> Cancer

[In Vitro]

氢、碳和其他元素的稳定重同位素已被掺入药物分子中，主要用作药物开发过程中定量的示踪剂。氘代因其可能影响药物的药代动力学和代谢特征而受到关注[1]。 MeIQx (0.47 mM；0-120 分钟) 与小鼠血红蛋白共价结合，并被小鼠微粒体激活为代谢物[2]。

[In Vivo]

MeIQx (2.0-200 mg/kg；腹腔注射) 在雄性 Swiss Webster 小鼠中，以剂量依赖性方式与血红蛋白共价结合[2]。

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.

[2]. Lynch AM, et, al. The measurement of MeIQx adducts with mouse haemoglobin in vitro and in vivo: implications for human dosimetry. Carcinogenesis. 1991 Jun;12(6):1067-72.

Chemical & Physical Properties

[ Density]:
1.5g/cm3

[ Boiling Point ]:
458.4ºC at 760 mmHg

[ Melting Point ]:
>264°C (dec.)

[ Molecular Formula ]:
C₁₁H₈D₃N₅

[ Molecular Weight ]:
216.26

[ Flash Point ]:
231ºC

[ Exact Mass ]:
216.12000

[ PSA ]:
69.62000

[ LogP ]:
1.98830

[ Vapour Pressure ]:
1.38E-08mmHg at 25°C

[ Index of Refraction ]:
1.776

[ Storage condition ]:
Refrigerator

Safety Information

[ Hazard Codes ]:
Xn

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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