(R)-Larotrectinib

Names

[ CAS No. ]:
1223404-68-9

[ Name ]:
(R)-Larotrectinib

Biological Activity

[Description]:

(R)-Larotrectinib is a potent TRK inhibitor with an IC50 value of 28.5 nM for TrkA. (R)-Larotrectinib can be used for researching cancer, inflammatory and certain infectious diseases[1]

[Related Catalog]:

Research Areas >> Cancer
Research Areas >> Infection
Research Areas >> Inflammation/Immunology
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Trk Receptor

[Target]

TrkA:28.5 nM (IC50)


[References]

[1]. Julia Haas, et al. SUBSTITUTED PYRAZOLO[1,5-a]PYRIMIDINE COMPOUNDS AS TRK KINASE INHIBITORS. WO2010048314A1 (compound 93)

Chemical & Physical Properties

[ Molecular Formula ]:
C21H22F2N6O2

[ Molecular Weight ]:
428.44

Related Compounds

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