CID44216842

Names

[ Name ]:
CID44216842

[Synonym ]:
MFCD28009507

Biological Activity

[Description]:

CID44216842 (Cdc42-IN-1) is a potent Cdc42-selective guanine nucleotide binding lead inhibitor. The EC50s for Cdc42 WT and Cdc42Q61L mutant are 1.0 and 1.2 μM in GTP binding assay, respectively. The EC50s for Cdc42 WT and Cdc42Q61L mutant are 0.3 and 0.5 μM in GDP binding assay, respectively. Use as a molecular probe[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> GPCR/G Protein >> Ras

[Target]

EC50: 1.0 μM (Cdc42 WT, in GTP binding assay) and 1.2 μM (Cdc42Q61L mutant, in GTP binding assay)[1] EC50: 0.3 μM (Cdc42 WT, in GDP binding assay) and 0.5 μM (Cdc42Q61L mutant, in GDP binding assay)[1]

[In Vitro]

CID44216842 inhibits GTP binding to both Cdc42 and its mutant in a dose-dependent manner. The inhibition is specific toward Cdc42 with no effects on other GTPases including Rac and Rho in the same family[1].

[References]

[1]. Lin Hong, et al. Characterization of a Cdc42 Protein Inhibitor and Its Use as a Molecular Probe. J Biol Chem. 2013 Mar 22;288(12):8531-43.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₂H₂₀BrN₃O₃S

[ Molecular Weight ]:
486.38

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ RIDADR ]:
NONH for all modes of transport

Related Compounds

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