JNJ-49095397

Names

[ CAS No. ]:
1220626-82-3

[ Name ]:
JNJ-49095397

[Synonym ]:
Jnj-49095397
Acetamide, N-[4-[[[4-[[[[3-(1,1-dimethylethyl)-1-(4-methylphenyl)-1H-pyrazol-5-yl]amino]carbonyl]amino]-1-naphthalenyl]oxy]methyl]-2-pyridinyl]-2-methoxy-
2-Methoxy-N-[4-({[4-({[1-(4-methylphenyl)-3-(2-methyl-2-propanyl)-1H-pyrazol-5-yl]carbamoyl}amino)-1-naphthyl]oxy}methyl)-2-pyridinyl]acetamide

Biological Activity

[Description]:

JNJ-49095397 (RV-568) is a specific narrow-spectrum kinase inhibitor that inhibits a selected set of kinases involved in COPD inflammation with IC50 of 5, 40 and 52 nM for p38α, p38γ and HCK, respectively; shows potent anti-inflammatory effects in monocytes and macrophages, demonstrates synergistic interaction in poly I:C-stimulated BEAS-2B cells and in the cigarette smoke model combined with corticosteroid. COPD Phase 2 Clinical

[References]

References 1. Onions ST, et al. J Med Chem. 2016 Mar 10;59(5):1727-46. 2. Charron CE, et al. Eur Respir J. 2017 Oct 26;50(4). pii: 1700188. View Related Products by Target p38 MAPK COPD

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
738.0±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C₃₄H₃₆N₆O₄

[ Molecular Weight ]:
592.687

[ Flash Point ]:
400.1±32.9 °C

[ Exact Mass ]:
592.279785

[ LogP ]:
6.50

[ Vapour Pressure ]:
0.0±2.4 mmHg at 25°C

[ Index of Refraction ]:
1.627

Related Compounds

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