Triisopropanolamine
Names
[ CAS No. ]:
122-20-3
[ Name ]:
Triisopropanolamine
[Synonym ]:
Nitrilotripropanol
1,1',1''-Nitrilotripropan-2-ol
1,1',1''-Nitrilotri(2-propanol)
UNII:W9EN9DLM98
Triisopropanolamine
2-Propanol, 1,1',1''-nitrilotris-
EINECS 204-528-4
MFCD00004533
1,1',1''-Nitrilotris-2-propanol
1-[bis(2-hydroxypropyl)amino]propan-2-ol
1,1',1''-Nitrilotri(-2-propanol)
Chemical & Physical Properties
[ Density]:
1.1±0.1 g/cm3
[ Boiling Point ]:
296.4±0.0 °C at 760 mmHg
[ Melting Point ]:
48-52 °C(lit.)
[ Molecular Formula ]:
C9H21NO3
[ Molecular Weight ]:
191.268
[ Flash Point ]:
167.0±21.0 °C
[ Exact Mass ]:
191.152145
[ PSA ]:
63.93000
[ LogP ]:
-0.07
[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C
[ Index of Refraction ]:
1.495
[ Freezing Point ]:
52℃
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- UB8750000
- CHEMICAL NAME :
- 2-Propanol, 1,1',1''-nitrilotri-
- CAS REGISTRY NUMBER :
- 122-20-3
- BEILSTEIN REFERENCE NO. :
- 1071570
- LAST UPDATED :
- 199710
- DATA ITEMS CITED :
- 13
- MOLECULAR FORMULA :
- C9-H21-N-O3
- MOLECULAR WEIGHT :
- 191.31
- WISWESSER LINE NOTATION :
- QY1&1N1YQ1&1YQ1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration into the eye
- SPECIES OBSERVED :
- Rodent - rabbit
- REFERENCE :
- AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918- Volume(issue)/page/year: 29,1363,1946 ** ACUTE TOXICITY DATA **
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 4730 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Gastrointestinal - hypermotility, diarrhea Nutritional and Gross Metabolic - body temperature decrease
- REFERENCE :
- GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 30(7),46,1986
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 2520 mg/kg
- TOXIC EFFECTS :
- Behavioral - muscle contraction or spasticity
- REFERENCE :
- GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 45(3),79,1980
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 11 gm/kg
- TOXIC EFFECTS :
- Behavioral - muscle contraction or spasticity
- REFERENCE :
- GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 45(3),79,1980
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 10 mL/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817) Volume(issue)/page/year: 4/21/1967
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 1580 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Gastrointestinal - other changes Kidney, Ureter, Bladder - other changes
- REFERENCE :
- JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. Volume(issue)/page/year: 23,259,1941
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Mammal - species unspecified
- DOSE/DURATION :
- >1 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 30(7),46,1986 ** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 28 gm/kg/2W-C
- TOXIC EFFECTS :
- Behavioral - food intake (animal) Kidney, Ureter, Bladder - changes in bladder weight
- REFERENCE :
- JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year: 6(1),53,1987 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M0259 No. of Facilities: 1842 (estimated) No. of Industries: 27 No. of Occupations: 44 No. of Employees: 23845 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M0259 No. of Facilities: 2702 (estimated) No. of Industries: 51 No. of Occupations: 58 No. of Employees: 64304 (estimated) No. of Female Employees: 8631 (estimated)
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H319-H412
[ Precautionary Statements ]:
P273-P305 + P351 + P338
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves
[ Hazard Codes ]:
Xi:Irritant;
[ Risk Phrases ]:
R36;R52/53
[ Safety Phrases ]:
S26-S61
[ RIDADR ]:
UN 3259 8/PG 2
[ WGK Germany ]:
1
[ RTECS ]:
UB8750000
[ Packaging Group ]:
III
[ Hazard Class ]:
8.0
[ HS Code ]:
2922199090
Synthetic Route
Customs
[ HS Code ]: 2922199090
[ Summary ]:
2922199090. other amino-alcohols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%
Articles
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The initiation potential of N-nitrosobis(2-hydroxypropyl)amine (NDHPA) endogenously synthesized from bis(2-hydroxypropyl)amine (DHPA) or tris(2-hydroxypropyl)amine (THPA) in the presence of sodium nit...
Autoclavable highly cross-linked polyurethane networks in ophthalmology.Biomaterials 14(14) , 1089-97, (1993)
Highly cross-linked aliphatic polyurethane networks have been prepared by the bulk step reaction of low molecular weight polyols and hexamethylenediisocyanate (HDI). These polyurethane networks are op...
Gas chromatographic determination of N-nitrosodialkanolamines in herbicide Di- or trialkanolamine formulations.J. Assoc. Off. Anal. Chem. 71(2) , 328-33, (1988)
A modified method is presented to determine trace quantities of N-nitrosodiethanolamine (NDElA) and N-nitrosodiisopropanolamine (NDiPlA) in the triisopropanolamine (TiPlA) formulation of a mixture of ...