Cetirizine-d4

Names

[ CAS No. ]:
1219803-84-5

[ Name ]:
Cetirizine-d4

[Synonym ]:
(±)-Cetirizine-d4 (ethoxy-d4)
(±)-Cetirizine-d4

Biological Activity

[Description]:

Cetirizine D4 is a deuterium labeled Cetirizine. Cetirizine, a second-generation antihistamine and the carboxylated metabolite of hydroxyzine, is a specific, orally active and long-acting histamine H1-receptor antagonist. Cetirizine marks antiallergic properties and inhibits eosinophil chemotaxis during the allergic response[1][2][3].

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor

Research Areas >> Inflammation/Immunology

Signaling Pathways >> GPCR/G Protein >> Histamine Receptor

[Target]

H1 receptor

[References]

[1]. Caroline M. Spencer, et al. Cetirizine. Drugs 46 (6): 1055•1080, 1993.

[2]. Shih MY, et al. Influence of cetirizine and levocetirizine on two cytokines secretion in human airway epithelial cells. Allergy Asthma Proc. 2008 Sep-Oct;29(5):480-5.

[3]. Shimizu T, et al. Cetirizine, an H1-receptor antagonist, suppresses the expression of macrophage migration inhibitory factor: its potential anti-inflammatory action. Clin Exp Allergy. 2004 Jan;34(1):103-9.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₁H₂₁D₄ClN₂O₃

[ Molecular Weight ]:
392.91200

[ Exact Mass ]:
392.18000

[ PSA ]:
53.01000

[ LogP ]:
3.02400

Related Compounds

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