(-)-Ibuprofenamide

Names

[ Name ]:
(-)-Ibuprofenamide

[Synonym ]:
(R)-2-(4-Isobutyl-phenyl)-propionamide
(R)-2-(4-isobutylphenyl)propionamide

Biological Activity

[Description]:

(-)-Ibuprofenamide is an amide prodrug of Ibuprofen with anti-inflammatory activity[1]. Ibuprofen is an anti-inflammatory inhibitor targeting COX-1 and COX-2 with IC50s of 13 μM and 370 μM, respectively[2].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

[Target]

COX-1, COX-2[2]

[References]

[1]. Shanbhag VR, et al. Ester and amide prodrugs of ibuprofen and naproxen: synthesis, anti-inflammatory activity, and gastrointestinal toxicity. J Pharm Sci. 1992 Feb;81(2):149-54.

[2]. Noreen Y, et al. Development of a radiochemical cyclooxygenase-1 and -2 in vitro assay for identification of natural products as inhibitors of prostaglandin biosynthesis. J Nat Prod. 1998 Jan;61(1):2-7.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₃H₁₉NO

[ Molecular Weight ]:
205.30

[ Exact Mass ]:
205.14700

[ PSA ]:
43.09000

[ LogP ]:
3.17420