Atorvastatin lactone D5

Names

[ Name ]:
Atorvastatin lactone D5

[Synonym ]:
5-(4-Fluorophenyl)-1-{2-[(2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl}-2-isopropyl-N-phenyl-4-(2H5)phenyl-1H-pyrrole-3-carboxamide
1H-Pyrrole-3-carboxamide, 5-(4-fluorophenyl)-2-(1-methylethyl)-N-phenyl-4-(phenyl-d5)-1-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-

Biological Activity

[Description]:

Atorvastatin lactone D5 is a deuterated form of Atorvastatin lactone (HY-101873). Atorvastatin lactone is a prodrug form of atorvastatin. Atorvastatin is an orally active 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> HMG-CoA Reductase (HMGCR)

Research Areas >> Inflammation/Immunology

Research Areas >> Metabolic Disease

[References]

[1]. Valesky RJ, et al. Automated enzyme inhibition assay method for the determination of atorvastatin-derived HMG-CoA reductase inhibitors in human plasma using radioactivity detection. J Pharmacol Toxicol Methods. 2008 Jan-Feb;57(1):61-9.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
674.8±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₃₃H₂₈D₅FN₂O₄

[ Molecular Weight ]:
545.655

[ Flash Point ]:
361.9±31.5 °C

[ Exact Mass ]:
545.273804

[ LogP ]:
4.30

[ Vapour Pressure ]:
0.0±2.2 mmHg at 25°C

[ Index of Refraction ]:
1.617

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.