BMS-929075

Names

[ Name ]:
BMS-929075

[Synonym ]:
4-Fluoro-2-(4-fluorophenyl)-N-methyl-5-(2-methyl-5-{[1-(2-pyrimidinyl)cyclopropyl]carbamoyl}phenyl)-1-benzofuran-3-carboxamide
MFCD31556637
BMS-929075
3-Benzofurancarboxamide, 4-fluoro-2-(4-fluorophenyl)-N-methyl-5-[2-methyl-5-[[[1-(2-pyrimidinyl)cyclopropyl]amino]carbonyl]phenyl]-

Biological Activity

[Description]:

A highly potent, selective, orally bioavailable HCV NS5B polymerase inhibitor with IC50 of 9, 4, and 18 nM for GT1a, GT1b, and GT1b-C316N mutant in HCV replicon assay, respectively; possesses excellent pharmacokinetic parameters across preclinical animal species. HCV Infection Phase 1 Clinical

[References]

References 1. Yeung KS, et al. J Med Chem. 2017 May 25;60(10):4369-4385. View Related Products by Target HCV HCV Infection

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
725.5±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C₃₁H₂₄F₂N₄O₃

[ Molecular Weight ]:
538.544

[ Flash Point ]:
392.6±32.9 °C

[ Exact Mass ]:
538.181641

[ LogP ]:
3.93

[ Vapour Pressure ]:
0.0±2.4 mmHg at 25°C

[ Index of Refraction ]:
1.684

Related Compounds

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