Amiloride-15N3 hydrochloride

Names

[ CAS No. ]:
1216796-18-7

[ Name ]:
Amiloride-15N3 hydrochloride

[Synonym ]:
2-Pyrazinecarboxamide-15N, 3,5-diamino-N-(amino-15Nimino-15N-methyl)-6-chloro-, hydrochloride (1:1)
3,5-Diamino-N-(15N2)carbamimidoyl-6-chloro-2-pyrazine(15N)carboxamide hydrochloride (1:1)

Biological Activity

[Description]:

Amiloride-15N3 (hydrochloride) is the 15N labeled Amiloride hydrochloride[1]. Amiloride hydrochloride (MK-870 hydrochloride) is an inhibitor of both epithelial sodium channel (ENaC[2]) and urokinase-type plasminogen activator receptor (uTPA[3]). Amiloride hydrochloride is a blocker of polycystin-2 (PC2;TRPP2[4]) channel.

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel
Signaling Pathways >> Apoptosis >> Apoptosis
Signaling Pathways >> Membrane Transporter/Ion Channel >> TRP Channel

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  

[2]. Ji, H.L., et al. delta ENaC: a novel divergent amiloride-inhibitable sodium channel. Am J Physiol Lung Cell Mol Physiol, 2012. 303(12): p. L1013-26.  

[3]. Teiwes J, et al. Epithelial sodium channel inhibition in cardiovascular disease. A potential role for amiloride. Am J Hypertens. 2007 Jan20(1):109-17.  

[4]. Giamarchi A, et al. A polycystin-2 (TRPP2) dimerization domain essential for the function of heteromeric polycystin complexes. EMBO J. 2010 Apr 729(7):1176-91.  

Chemical & Physical Properties

[ Molecular Formula ]:
C6H9Cl2N415N3O

[ Molecular Weight ]:
269.068

[ Exact Mass ]:
268.015656

Related Compounds