14-Chloro Daunorubicin
Names
[ CAS No. ]:
121250-06-4
[ Name ]:
14-Chloro Daunorubicin
[Synonym ]:
14-chlorodaunorubicin
14-ChlororuboMycin
10-(4-amino-5-hydroxy-6-methyl-oxan-2-yl)oxy-8-(2-chloroacetyl)-6,8,11-trihydroxy-1-methoxy-9,10-dihydro-7H-tetracene-5,12-dione
14-ChlorodaunoMycin
Chemical & Physical Properties
[ Density]:
1.6g/cm3
[ Boiling Point ]:
793.8ºC at 760mmHg
[ Molecular Formula ]:
C27H28ClNO10
[ Molecular Weight ]:
561.96500
[ Flash Point ]:
433.9ºC
[ Exact Mass ]:
561.14000
[ PSA ]:
185.84000
[ LogP ]:
1.94810
[ Vapour Pressure ]:
1.43E-26mmHg at 25°C
[ Index of Refraction ]:
1.695
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- QI9325500
- CHEMICAL NAME :
- 5,12-Naphthacenedione, 7,8,9,10-tetrahydro-10-((3-amino-2,3,6-trideoxy-alpha -L-lyxo- hexopyranosyl)oxy)-8-(chloroacetyl)-1-methoxy-6,8,11- trihydroxy-, (8S-cis)-
- CAS REGISTRY NUMBER :
- 121250-06-4
- LAST UPDATED :
- 199206
- DATA ITEMS CITED :
- 1
- MOLECULAR FORMULA :
- C27-H28-Cl-N-O10
- MOLECULAR WEIGHT :
- 562.01
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 33500 ug/kg
- TOXIC EFFECTS :
- Tumorigenic - active as anti-cancer agent
- REFERENCE :
- ANKHEW Antibiotiki i Khimioterapiya. Antibiotics and Chemotherapy. (V/O Me zhdunarodnaya Kniga, 113095 Moskow, USSR) V.33- 1988- Volume(issue)/page/year: 35(2),24,1990