Sp-5,6-Dichloro-cBIMPS

Names

[ CAS No. ]:
120912-54-1

[ Name ]:
Sp-5,6-Dichloro-cBIMPS

[Synonym ]:
Sp 5,6-DCl-cBIMPS
MFCD06795834
5,6-DCL-CBIMPSASP-ISOMER
5,6-Dichloro-1-B-D-ribofuranosylbenzimidazole-3'',5''-cyclic monophosphothioa

Biological Activity

[Description]:

Sp-5,6-DCl-cBIMPS is a potent and specific cAMP-dependent protein kinases (cAMP-PK) activator. Sp-5,6-DCl-cBIMPS stimulates insulin release. Sp-5,6-DCl-cBIMPS inhibits U46619-induced activation of Rho, Gq and G12/G13 in platelets[1][2][3].

[Related Catalog]:

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> PKA

Signaling Pathways >> Stem Cell/Wnt >> PKA

Research Areas >> Metabolic Disease

[In Vitro]

Sp-5,6-DCl-cBIMPS (0.005, 0.05, 0.5 mM; 60 min) 以剂量和时间依赖性方式刺激离体胰岛释放胰岛素[2]。 Sp-5,6-DCl-cBIMPS (0.005, 0.05, 0.5 mM; 60 min) 增加葡萄糖 (8.5 mM) 刺激的胰岛素释放[2]。 SSp-5,6-DCl-cBIMPS (100 µM; 20 min) 抑制野生型小鼠血小板中 U46619 诱导的 Rho 激活，并抑制 U46619 诱导的人血小板中 Gq 和 G12/G13 激活[3 ]。 Western Blot Analysis[3] Cell Line: Wild-type mice, Human platelets Concentration: 100 µM Incubation Time: 20 min Result: Strongly suppressed U46619-induced Rho activation in wild-type, and inhibited U46619-induced activation of both Gq and G12/G13.

[References]

[1]. Sandberg M, et al. Characterization of Sp-5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole- 3',5'-monophosphorothioate (Sp-5,6-DCl-cBiMPS) as a potent and specific activator of cyclic-AMP-dependent protein kinase in cell extracts and intact cells. Biochem J. 1991 Oct 15;279 ( Pt 2)(Pt 2):521-7.

[2]. Laychock SG. Sp-5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole-3',5'-cyclic monophosphorothioate is a potent stimulus for insulin release. Endocr Res. 1993;19(2-3):113-22.

[3]. Gratacap MP, et al. Differential regulation of Rho and Rac through heterotrimeric G-proteins and cyclic nucleotides. J Biol Chem. 2001 Dec 21;276(51):47906-13.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₂H₁₀Cl₂N₂NaO₅PS

[ Molecular Weight ]:
419.15300

[ Exact Mass ]:
417.93200

[ PSA ]:
130.70000

[ LogP ]:
3.32240

Safety Information

[ WGK Germany ]:
3

Related Compounds

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