physalin O

Names

[ CAS No. ]:
120849-18-5

[ Name ]:
physalin O

Biological Activity

[Description]:

Physalin O is a physalin that can be isolated from Physalis angulata. Physalin O shows cytotoxicity to Hep G2 and MCF-7 cancer cells with IC50 values of 31.1 and 11.4 µM, respectively. Physalin O inhibits the production of nitric oxide (NO) and shows anti-inflammatory activities[1][2].

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> NO Synthase

Research Areas >> Inflammation/Immunology

[References]

[1]. Kuo PC, et al. Physanolide A, a novel skeleton steroid, and other cytotoxic principles from Physalis angulata. Org Lett. 2006 Jul 6;8(14):2953-6.

[2]. Ji L, et al. Physalins with anti-inflammatory activity are present in Physalis alkekengi var. franchetii and can function as Michael reaction acceptors. Steroids. 2012 Apr;77(5):441-7.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₈H₃₂O₁₀

[ Molecular Weight ]:
528.54800

[ Exact Mass ]:
528.20000

[ PSA ]:
156.66000

[ LogP ]:
0.50980

Related Compounds

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