4-Chloro-3-sulfamoylbenzoic acid
Names
[ CAS No. ]:
1205-30-7
[ Name ]:
4-Chloro-3-sulfamoylbenzoic acid
[Synonym ]:
Benzoic acid, 3-(aminosulfonyl)-4-chloro-
EINECS 214-882-1
4-Chloro-3-sulfamoylbenzoic acid
MFCD00012375
3-(aminosulfonyl)-4-chlorobenzoic acid
Chemical & Physical Properties
[ Density]:
1.6±0.1 g/cm3
[ Boiling Point ]:
502.4±60.0 °C at 760 mmHg
[ Melting Point ]:
256-258 °C(lit.)
[ Molecular Formula ]:
C7H6ClNO4S
[ Molecular Weight ]:
235.645
[ Flash Point ]:
257.6±32.9 °C
[ Exact Mass ]:
234.970612
[ PSA ]:
105.84000
[ LogP ]:
0.92
[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C
[ Index of Refraction ]:
1.622
[ Storage condition ]:
Refrigerator
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- DG5642600
- CHEMICAL NAME :
- Benzoic acid, 4-chloro-3-sulfamoyl-
- CAS REGISTRY NUMBER :
- 1205-30-7
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 2
- MOLECULAR FORMULA :
- C7-H6-Cl-N-O4-S
- MOLECULAR WEIGHT :
- 235.65
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1100 mg/kg
- TOXIC EFFECTS :
- Behavioral - tremor Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory depression
- REFERENCE :
- KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 16,2275,1982
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >2 gm/kg
- TOXIC EFFECTS :
- Behavioral - tremor Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory depression
- REFERENCE :
- KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 16,2275,1982
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H315-H319-H335
[ Precautionary Statements ]:
P261-P305 + P351 + P338
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves
[ Hazard Codes ]:
Xi:Irritant
[ Risk Phrases ]:
R36/37/38
[ Safety Phrases ]:
S26-S37/39
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
3
[ RTECS ]:
DG5642600
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Articles
Jpn. J. Pharmacol. 32(6) , 1041-9, (1982)
The metabolic fate of a new antihypertensive agent, tripamide (N-(4-aza-endo-tricyclo[5.2.1.0(2,6))]-decan-4-yl)-4-chloro-3-sulfamoylbenzamide), in rats and rabbits was studied using its 14C-labeled c...
Chromatographic-densitometric Method for Determination of Clopamide and 4-chlorobenzoic, and 4-chloro-3-sulfamoylbenzoic Acids in Tablets. Hubicka U, et al.Curr. Pharm. Anal. 5(4) , 408-15, (2009)