Azido-PEG8-NHS ester

Names

[ CAS No. ]:
1204834-00-3

[ Name ]:
Azido-PEG8-NHS ester

Biological Activity

[Description]:

Azido-PEG8-NHS ester is a cleavable 8 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Azido-PEG8-NHS ester is also a PEG- and Alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[2].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

Alkyl/ether

Cleavable

[In Vitro]

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].

[References]

[1]. Mahendra Persaud Deonarain, et al. Biological materials and uses thereof. WO2016046574A1.

[2]. Rong Yuan, et al. Viruslike Element-Tagged Nanoparticle Inductively Coupled Plasma Mass Spectrometry Signal Multiplier: Membrane Biomarker Mediated Cell Counting. Analytical Chemistry (Washington, DC, United States) (2019), 91(8), 4948-4952.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₃H₄₀N₄O₁₂

[ Molecular Weight ]:
564.58300

[ Exact Mass ]:
564.26400

[ PSA ]:
187.27000

[ Storage condition ]:
-20°C

Related Compounds

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