ER 27319 maleate

Names

[ CAS No. ]:
1204480-26-1

[ Name ]:
ER 27319 maleate

[Synonym ]:
10-(3-Aminopropyl)-3,4-dimethylacridin-9(10H)-one (2Z)-but-2-enedioate (1:1)
9(10H)-Acridinone, 10-(3-aminopropyl)-3,4-dimethyl-, (2Z)-2-butenedioate (1:1)
10-(3-Aminopropyl)-3,4-dimethyl-9(10H)-acridinone (2Z)-2-butenedioate (1:1)

Biological Activity

[Description]:

ER-27319 maleate is a potent, selective inhibitor of antigen or anti-IgE-mediated degranulation of rodent and human mast cells by selective inhibition of FcɛRI-mediated activation of Syk; does not inhibits the anti-CD3-induced tyrosine phosphorylation of phospholipase C-gamma1 in Jurkat T cells.

[References]

References 1. Moriya K, et al. Proc Natl Acad Sci U S A. 1997 Nov 11;94(23):12539-44. 2. Andrews RP, et al. J Leukoc Biol. 2001 Nov;70(5):776-82. View Related Products by Target Syk

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₈H₂₀N₂O_.C₄H₄O₄

[ Molecular Weight ]:
396.436

[ Exact Mass ]:
396.168518

Related Compounds

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