Verlukast

Names

[ CAS No. ]:
120443-16-5

[ Name ]:
Verlukast

[Synonym ]:
3-{[(R)-{3-[(E)-2-(7-Chloroquinolin-2-yl)vinyl]phenyl}{[3-(dimethylamino)-3-oxopropyl]sulfanyl}methyl]sulfanyl}propanoic acid
Propanoic acid, 3-[[(R)-[3-[(E)-2-(7-chloro-2-quinolinyl)ethenyl]phenyl][[3-(dimethylamino)-3-oxopropyl]thio]methyl]thio]-
MK 679
3-(((aR)-m-((E)-2-(7-Chloro-2-quinolyl)vinyl)-a-((2-(dimethylcarbamoyl)ethyl)thio)benzyl)thio)propionic Acid
3-{[(R)-{3-[(E)-2-(7-Chloro-2-quinolinyl)vinyl]phenyl}{[3-(dimethylamino)-3-oxopropyl]sulfanyl}methyl]sulfanyl}propanoic acid
Verlukastum
(R-(E))-3-(((3-(2-(7-Chloro-2-quinolinyl)ethenyl)phenyl)((3-(dimethylamino)-3-oxopropyl)thio)methyl)thio)propanoic Acid
3-(((αR)-m-((E)-2-(7-Chloro-2-quinolyl)vinyl)-α-((2-(dimethylcarbamoyl)ethyl)thio)benzyl)thio)propionic acid
3-{[(R)-{3-[(E)-2-(7-chloroquinolin-2-yl)ethenyl]phenyl}{[3-(dimethylamino)-3-oxopropyl]sulfanyl}methyl]sulfanyl}propanoic acid
MK-0679
VERLUKAST

Biological Activity

[Description]:

Verlukast is a potent, selective, and orally active antagonist of leukotriene receptor. Verlukast has the potential for the research of asthma[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Leukotriene Receptor

Research Areas >> Inflammation/Immunology

[Target]

leukotriene receptor[1]

[References]

[1]. Dahlén B, et al. Effect of the leukotriene receptor antagonist MK-0679 on baseline pulmonary function in aspirin sensitive asthmatic subjects. Thorax. 1993;48(12):1205-1210.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
712.3±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₆H₂₇ClN₂O₃S₂

[ Molecular Weight ]:
515.087

[ Flash Point ]:
384.6±32.9 °C

[ Exact Mass ]:
514.115173

[ PSA ]:
121.10000

[ LogP ]:
5.93

[ Vapour Pressure ]:
0.0±2.4 mmHg at 25°C

[ Index of Refraction ]:
1.687

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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